Can Herba Cistanches Protect against Statin-Induced Muscle Toxicity?
Refereed conference paper presented and published in conference proceedings


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摘要Statins, the cholesterol lowering drugs, are well known to cause myotoxicity in some patients [1]. Herba Cistanches (HC, Cistanche deserticola) is a Chinese herb traditionally used for muscle problems. Recent studies showed that HC extract could reduce muscle damage and improve ATP storage in post-exercised mice [2], though its effect (including its chemical marker verbascoside) on statin-induced muscle toxicity has never been investigated. Hence, we hypothesized that HC could prevent muscle toxicity induced by statins. The assessment was made on the basis of the in vitro and in vivo abilities of HC water extract (HCE) to reduce simvastatin-induced muscle toxicity.

Our in vitro data demonstrated that HCE (0 – 2 mg/ml) could exert dose-dependent protective effect on simvastatin (10µM)-induced apoptotic and necrotic cells, possibly via caspase-3 pathway. Simvastatin reduced the ATP production in L6 cells, which was dose-dependently prevented by HCE. However, there was no significant effect of verbascoside (0 – 160µM) on the protection of simvastatin-induced muscle toxicity. In our in vivo simvastatin-induced muscle toxicity rat model, results showed that simvastatin (640 mg/kg) significantly reduced quadriceps and gastrocnemius muscle weight. Both HCE (1.1 and 2.2 g/kg) and verbascoside (1.87 and 3.74 mg/kg) dose-dependently improved the muscle weights of both muscles. HCE, but not verbascoside, also significantly reduced simvastatin-induced increase in plasma creatine kinase levels. Simvastatin caused a significant reduction on muscle mitochondrial permeability potential and reactive oxygen species levels, which could be reversed by HCE.

In conclusion, we have for the first time demonstrated that HCE could significantly improve the simvastatin-induced muscle toxicity in vitro and in vivo, while verbascoside might be partly responsible for the effect. These data indicate the potential adjuvant use of HCE in patients who suffer from simvastatin-induced myotoxicity.
著者WAT Chi Ling Elaine, NG Chun Fai, KOON Chi Man, CHAN Yau Tsz, TSO Tiffany Hoi Ka, TOMLINSON Brian, LAU Bik San Clara
會議名稱9th Joint Natural Products Conference 2016
會議開始日24.07.2016
會議完結日27.07.2016
會議地點Copenhagen
會議國家/地區丹麥
會議論文集題名Planta Medica
出版年份2016
月份7
日期24
卷號82
期次S01
出版地Denmark, Copenhagen
頁次P856
國際標準期刊號0032-0943
語言英式英語

上次更新時間 2020-20-11 於 02:15