Deciphering the Role of microRNAs in Regulation of Immune Surveillance, Self-tolerance and Allograft Transplantation
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AbstractMicroRNAs are small non-coding RNAs that can modulate gene expression at post-transcriptional level, and they participate in almost all important biological processes. Immune system is elaborately regulated to maintain the equilibrium between immunity and tolerance. Recent studies have revealed the significant functions of microRNAs in maintenance of immune homeostasis using both cell and transgenic mouse models. In collaboration with various transcriptional factors, cytokines and chemokines, microRNAs constitute an effective and flexible regulatory network governing the development and activation of immune cells; as well as maintenance of immune tolerance. In this review, microRNAs involved in T cell development, proliferation, and lineage differentiation will be summarized. Based on current knowledge, the function of microRNAs in establishing and maintaining immune tolerance will also be discussed in relation to determining the outcome of allograft transplantation.
All Author(s) ListLEUNG She Ting Cherry, LU Song, LI, Jiatao, WU Ka Kei, LUI O. Kathy
Journal nameCurrent Stem Cell Research and Therapy
Volume Number13
Issue Number5
Pages336 - 344
LanguagesEnglish-United Kingdom
KeywordsmicroRNAs; immune surveillance; self-tolerance

Last updated on 2021-16-09 at 01:17