Differentiation of Isomeric Ginsenosides by Using Electron-Induced Dissociation Mass Spectrometry
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AbstractCurrent phytochemical research on ginsengs focuses on the structural characterization and isomer differentiation of ginsenosides. In this Letter, electron-induced dissociation (EID) was initially investigated by analyzing isomeric ginsenosides. EID provided more structural information on their differentiation than collision-induced dissociation (CID) did. Glycosyl group migration previously observed in the CID of oligosaccharide ions could also be found in the EID of protonated Rg(1). This rearrangement reaction would show substantial ambiguities in differentiating Rg(1) from Rf. Although other charge carriers could alleviate this problem, the use of EID in dissociating deprotonated ginsenoside ions was superior to other techniques in terms of eliminating glycosyl group migration and generating diagnostic fragment ions for the differentiation of structural isomers. This study demonstrates a potential method to analyze natural products and thus help discover and evaluate novel compounds.
All Author(s) ListWong YLE, Chen XF, Li W, Wang Z, Hung YLW, Wu R, Chan TWD
Journal nameAnalytical Chemistry,Analytical Chemistry
Volume Number88
Issue Number11
Pages5590 - 5594
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesChemistry; Chemistry, Analytical

Last updated on 2020-28-10 at 02:16