Selective Modulation of Histaminergic Inputs on Projection Neurons of Cerebellum Rapidly Promotes Motor Coordination via HCN Channels
Publication in refereed journal

香港中文大學研究人員

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摘要Insights into function of central histaminergic system, a general modulator originating from the hypothalamus for whole brain activity, in motor control are critical for understanding the mechanism underlying somatic-nonsomatic integration. Here, we show a novel selective role of histamine in the cerebellar nuclei, the final integrative center and output of the cerebellum. Histamine depolarizes projection neurons but not interneurons in the cerebellar nuclei via the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels coupled to histamine H2 receptors, which are exclusively expressed on glutamatergic and glycinergic projection neurons. Furthermore, blockage of HCN channels to block endogenous histaminergic afferent inputs in the cerebellar nuclei significantly attenuates motor balance and coordination. Therefore, through directly and quickly modulation on projection neurons but not interneurons in the cerebellar nuclei, central histaminergic system may act as a critical biasing force to not only promptly regulate ongoing movement but also realize a rapid integration of somatic and nonsomatic response.
著者Zhang J, Zhuang QX, Li B, Wu GY, Yung WH, Zhu JN, Wang JJ
期刊名稱Molecular Neurobiology
出版年份2016
月份3
日期1
卷號53
期次2
出版社HUMANA PRESS INC
頁次1386 - 1401
國際標準期刊號0893-7648
電子國際標準期刊號1559-1182
語言英式英語
關鍵詞Cerebellar nuclei; HCN channel; Histamine; Histamine H2 receptor; Motor control; Projection neurons
Web of Science 學科類別Neurosciences; Neurosciences & Neurology

上次更新時間 2020-20-10 於 03:16