Effect of daily short-duration weight-bearing on disuse-induced deterioration of musculoskeletal system
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AbstractObjectives: To investigate deterioration of musculoskeletal system due to prolonged disuse and the potential of daily short-duration weight-bearing as countermeasures. Methods: Twenty-four adult male Sprague-Dawley rats were divided into Control Group (CG, no intervention), Tail-suspension Group (TG, tail-suspension without treatment), and Weight-Bearing Group (WBG, tail-suspension with 20 min/day, 5 days/week body weight loading). After four weeks of treatment, femur and tibia, soleus and extensor digitorum longus were evaluated for bone and muscle quality respectively. Tensile properties of bone-tendon insertion (BTI) were evaluated using patella-patellar tendon complex. Results: Disuse induced deterioration on bone, muscle, and BTI after four weeks. Compared with CG, TG and WBG showed significant decrease in bone mineral density (BMD) of trabecular bone in distal femur (4.3-15.2%), muscle mass (31.3-52.3%), muscle cross-sectional area (29.1-35%), and failure strength of BTI (23.9-29.4%). Tensile test showed that the failure mode was avulsion of bone at the BTI. No significant difference was detected between TG and WBG for all assessments on bone, muscle, and BTI. Conclusions: Disuse caused deterioration of bone, muscle, and BTI while daily short-duration of weight-bearing did not prevent this deterioration. Mechanical stimulation with higher intensity and longer duration may be necessary to prevent musculoskeletal deterioration resulted from prolonged disuse.
All Author(s) ListLeung KS, Li YH, Liu Y, Wang H, Tam KF, Chow DHK, Wan Y, Ling S, Dai Z, Qin L, Cheung WH
Journal nameJournal of Musculoskeletal and Neuronal Interactions
Volume Number15
Issue Number2
Pages207 - 214
LanguagesEnglish-United Kingdom
KeywordsBone Mineral Density; Bone-Tendon Insertion; Disuse-Induced Deterioration; Muscle; pQCT
Web of Science Subject CategoriesNeurosciences; Neurosciences & Neurology; Physiology

Last updated on 2020-24-05 at 01:24