In vitro transport assays of rufinamide, pregabalin, and zonisamide by human P-glycoprotein
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摘要Objective: Epilepsy is resistant to treatment with antiepileptic drugs (AEDs) in about one third of epilepsy patients. AED export by P-glycoprotein (Pgp) overexpressed in the blood brain barrier may contribute to AED resistance. The Pgp transport status of many of the recently approved AEDs remains unknown. We investigated whether several new AEDs zonisamide (ZNS), pregabalin (PGB), and rufinamide (RFM) are human Pgp substrates.
著者Chan PS, Zhang CB, Zuo Z, Kwan P, Baum L
期刊名稱Epilepsy Research
出版年份2014
月份3
日期1
卷號108
期次3
出版社ELSEVIER SCIENCE BV
頁次359 - 366
國際標準期刊號0920-1211
電子國際標準期刊號1872-6844
語言英式英語
關鍵詞ABCB1; MDR1; Pgp; Pregabalin; Rufinamide; Zonisamide
Web of Science 學科類別Clinical Neurology; CLINICAL NEUROLOGY; Neurosciences & Neurology

上次更新時間 2020-25-11 於 03:08