A novel anti-fibrotic agent, baicalein, for the treatment of myocardial fibrosis in spontaneously hypertensive rats
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摘要Myocardial interstitial fibrosis causes left ventricular stiffness and diastolic dysfunction. Despite its clinical significance, treatment options are limited. The flavonoid baicalein, extracted from roots of a Chinese medicinal plant, Scutellaria baicalensis Georgi was shown to inhibit liver fibrosis. This study sought to investigate whether chronic treatment with baicalein could attenuate myocardial fibrosis in spontaneously hypertensive rats (SHR). SHR were treated daily with baicalein while the control group received vehicle. At the end of study, SHR control group developed significant myocardial fibrosis that was attenuated by baicalein treatment for 4 and 12 weeks. Rats treated with baicalein were protected against an increase in heart to body weight ratio, plasma level of brain natriuretic peptides, intraventricular septum thickness, myocardial collagen volume of left ventricle (all P < 0.05, respectively). The antifibrotic effects of baicalein were further illustrated by the suppressed expression of left ventricle pro-collagens land Ill accompanied by the decreased expression of 12-lipoxygenase, and by reduced expression and activity of matrix metallopeptidase 9 and extracellular signal-regulated kinases. The present results show for the first time that baicalein can inhibit cardiac fibrosis in hypertensive rats. (C) 2011 Elsevier B.V. All rights reserved.
著者Kong EKC, Yu S, Sanderson JE, Chen KB, Huang Y, Yu CM
期刊名稱European Journal of Pharmacology,European Journal of Pharmacology
出版年份2011
月份5
日期11
卷號658
期次2-3
出版社ELSEVIER SCIENCE BV
頁次175 - 181
國際標準期刊號0014-2999
電子國際標準期刊號1879-0712
語言英式英語
關鍵詞Baicalein; Cardiac fibrosis; Collagen; Hypertension; Rat
Web of Science 學科類別Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

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