Host-response biomarkers for diagnosis of late-onset septicemia and necrotizing enterocolitis in preterm infants
Publication in refereed journal


引用次數
替代計量分析
.

其它資訊
摘要Preterm infants are highly susceptible to life-threatening infections that are clinically difficult to detect, such as late-onset septicemia and necrotizing enterocolitis (NEC). Here, we used a proteomic approach to identify biomarkers for diagnosis of these devastating conditions. In a case-control study comprising 77 sepsis/NEC and 77 nonsepsis cases (10 in each group being monitored longitudinally), plasma samples collected at clinical presentation were assessed in the biomarker discovery and independent validation phases. We validated the discovered biomarkers in a prospective cohort study with 104 consecutively suspected sepsis/NEC episodes. Proapolipoprotein CII (Pro-apoC2) and a des-arginine variant of serum amyloid A (SAA) were identified as the most promising biomarkers. The ApoSAA score computed from plasma apoC2 and SAA concentrations was effective in identifying sepsis/NEC cases in the case-control and cohort studies. Stratification of infants into different risk categories by the ApoSAA score enabled neonatologists to withhold treatment in 45% and enact early stoppage of antibiotics in 16% of nonsepsis infants. The negative predictive value of this antibiotic policy was 100%. The ApoSAA score could potentially allow early and accurate diagnosis of sepsis/NEC. Upon confirmation by further multicenter trials, the score would facilitate rational prescription of antibiotics and target infants who require urgent treatment.
著者Ng PC, Ang IL, Chiu RWK, Li KR, Lam HS, Wong RPO, Chui KM, Cheung HM, Ng EWY, Fok TF, Sung JJY, Lo YMD, Poon TCW
期刊名稱Journal of Clinical Investigation,Journal of Clinical Investigation
詳細描述To ORKTS: 2009 Impact factor (ISI knowledge): 15.4
出版年份2010
月份8
日期1
卷號120
期次8
出版社AMER SOC CLINICAL INVESTIGATION INC
頁次2989 - 3000
國際標準期刊號0021-9738
電子國際標準期刊號1558-8238
語言英式英語
Web of Science 學科類別Medicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Research & Experimental Medicine

上次更新時間 2020-18-09 於 01:24