Tyk2/STAT3 Signaling Mediates beta-Amyloid-Induced Neuronal Cell Death: Implications in Alzheimer's Disease
Publication in refereed journal

香港中文大學研究人員

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摘要One of the pathological hallmarks of Alzheimer's disease (AD) is deposition of extracellular amyloid-beta(A beta) peptide, which is generated from the cleavage of amyloid precursor protein (APP). Accumulation of A beta is thought to associate with the progressive neuronal death observed in AD. However, the precise signaling mechanisms underlying the action of A beta in AD pathophysiology are not completely understood. Here, we report the involvement of the transcription factor signal transducer and activator of transcription 3 (STAT3) in mediating A beta -induced neuronal death. We find that tyrosine phosphorylation of STAT3 is elevated in the cortex and hippocampus of APP/PS1 transgenic mice. Treatment of cultured rat neurons with A beta or intrahippocampal injection of mice with A beta both induces tyrosine phosphorylation of STAT3 in neurons. Importantly, reduction of either the expression or activation of STAT3 markedly attenuates A beta-induced neuronal apoptosis, suggesting that STAT3 activation contributes to neuronal death after A beta exposure. We further identify Tyk2 as the tyrosine kinase that acts upstream of STAT3, as A beta-induced activation of STAT3 and caspase-3-dependent neuronal death can be inhibited in tyk2(-/-) neurons. Finally, increased tyrosine phosphorylation of STAT3 is also observed in postmortem brains of AD patients. Our observations collectively reveal a novel role of STAT3 in A beta -induced neuronal death and suggest the potential involvement of Tyk2/STAT3 signaling in AD pathophysiology.
著者Wan J, Fu AKY, Ip FCF, Ng HK, Hugon J, Page G, Wang JH, Lai KO, Wu ZG, Ip NY
期刊名稱Journal of Neuroscience
出版年份2010
月份5
日期19
卷號30
期次20
出版社SOC NEUROSCIENCE
頁次6873 - 6881
國際標準期刊號1529-2401
語言英式英語
Web of Science 學科類別Neurosciences; NEUROSCIENCES; Neurosciences & Neurology

上次更新時間 2021-28-02 於 01:37