Functional Role of Vanilloid Transient Receptor Potential 4-Canonical Transient Receptor Potential 1 Complex in Flow-Induced Ca2+ Influx
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AbstractObjective-The present study is aimed at investigating the interaction of TRPV4 with TRPC1 and the functional role of such an interaction in flow-induced Ca2+ influx. Hemodynamic blood flow is an important physiological factor that modulates vascular tone. One critical early event in this process is a cytosolic Ca2+ ([Ca2+](i)) rise in endothelial cells in response to flow.
All Author(s) ListMa X, Qiu S, Luo JH, Ma Y, Ngai CY, Shen B, Wong CO, Huang Y, Yao XQ
Journal nameArteriosclerosis, Thrombosis, and Vascular Biology
Year2010
Month4
Day1
Volume Number30
Issue Number4
PublisherLIPPINCOTT WILLIAMS & WILKINS
Pages851 - U563
ISSN1079-5642
eISSN1524-4636
LanguagesEnglish-United Kingdom
KeywordsCa2+ flow; physical interaction; TRPC1; TRPV4
Web of Science Subject CategoriesCardiovascular System & Cardiology; Hematology; HEMATOLOGY; Peripheral Vascular Disease; PERIPHERAL VASCULAR DISEASE

Last updated on 2020-14-08 at 00:23