Cardiovascular risks and metabolic syndrome in Hong Kong Chinese women with polycystic ovary syndrome
Publication in refereed journal


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摘要BACKGROUND: Women with polycystic ovary syndrome (PCOS) frequently exhibit central obesity, glucose intolerance, atherogenic dyslipidaemia and hypertension which are characteristic features of the metabolic syndrome (MetS). METHODS: A total of 295 premenopausal Chinese women with PCOS diagnosed by the Rotterdam criteria (mean age: 30.2 +/- 6.4 years) and 98 control subjects without PCOS were evaluated for prevalence of MetS and cardiovascular risk factors, including dyslipidaemia and dysglycaemia. RESULTS: Using the 2005 modified Adult Treatment Panel III criteria, MetS (presence of three or more risk factors) was found in 24.9% of PCOS women compared to 3.1% of controls. The prevalence of MetS in PCOS women increased from 16.7% at under 30 years of age to 53.3% at over 40 years. MetS was also more prevalent in overweight and obese (41.3%) than normal-weight PCOS women (0.9%). However, multivariate regression analysis showed that women with PCOS had a 5-fold increase in risk of MetS (odds ratio 4.90; 95% confidence interval: 1.35-17.84) compared with women without PCOS even after controlling for age and BMI, suggesting PCOS alone is an independent risk factor for MetS. CONCLUSIONS: There is high prevalence of MetS in Hong Kong Chinese women with PCOS despite their relatively young age. Recognition of these cardiometabolic risk factors requires a high level of awareness in conjunction with early and regular screening.
著者Cheung LP, Ma RCW, Lam PM, Lok IH, Haines CJ, So WY, Tong PCY, Cockram CS, Chow CC, Goggins WB
期刊名稱Human Reproduction
詳細描述To ORKTS: This work was done while Cheung Lai Ping was a student under the supervision of Professor William Goggins
出版年份2008
月份6
日期1
卷號23
期次6
出版社OXFORD UNIV PRESS
頁次1431 - 1438
國際標準期刊號0268-1161
電子國際標準期刊號1460-2350
語言英式英語
關鍵詞Chinese; metabolic syndrome; polycystic ovary syndrome
Web of Science 學科類別Obstetrics & Gynecology; OBSTETRICS & GYNECOLOGY; Reproductive Biology; REPRODUCTIVE BIOLOGY

上次更新時間 2021-25-01 於 02:19