Cardiovascular risks and metabolic syndrome in Hong Kong Chinese women with polycystic ovary syndrome
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AbstractBACKGROUND: Women with polycystic ovary syndrome (PCOS) frequently exhibit central obesity, glucose intolerance, atherogenic dyslipidaemia and hypertension which are characteristic features of the metabolic syndrome (MetS). METHODS: A total of 295 premenopausal Chinese women with PCOS diagnosed by the Rotterdam criteria (mean age: 30.2 +/- 6.4 years) and 98 control subjects without PCOS were evaluated for prevalence of MetS and cardiovascular risk factors, including dyslipidaemia and dysglycaemia. RESULTS: Using the 2005 modified Adult Treatment Panel III criteria, MetS (presence of three or more risk factors) was found in 24.9% of PCOS women compared to 3.1% of controls. The prevalence of MetS in PCOS women increased from 16.7% at under 30 years of age to 53.3% at over 40 years. MetS was also more prevalent in overweight and obese (41.3%) than normal-weight PCOS women (0.9%). However, multivariate regression analysis showed that women with PCOS had a 5-fold increase in risk of MetS (odds ratio 4.90; 95% confidence interval: 1.35-17.84) compared with women without PCOS even after controlling for age and BMI, suggesting PCOS alone is an independent risk factor for MetS. CONCLUSIONS: There is high prevalence of MetS in Hong Kong Chinese women with PCOS despite their relatively young age. Recognition of these cardiometabolic risk factors requires a high level of awareness in conjunction with early and regular screening.
All Author(s) ListCheung LP, Ma RCW, Lam PM, Lok IH, Haines CJ, So WY, Tong PCY, Cockram CS, Chow CC, Goggins WB
Journal nameHuman Reproduction
Detailed descriptionTo ORKTS: This work was done while Cheung Lai Ping was a student under the supervision of Professor William Goggins
Year2008
Month6
Day1
Volume Number23
Issue Number6
PublisherOXFORD UNIV PRESS
Pages1431 - 1438
ISSN0268-1161
eISSN1460-2350
LanguagesEnglish-United Kingdom
KeywordsChinese; metabolic syndrome; polycystic ovary syndrome
Web of Science Subject CategoriesObstetrics & Gynecology; OBSTETRICS & GYNECOLOGY; Reproductive Biology; REPRODUCTIVE BIOLOGY

Last updated on 2021-17-02 at 01:29