Methylenetetrahydrofolate reductase gene A222V polymorphism and risk of ischemic stroke
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摘要The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene 677C-->T polymorphism causes an A222V amino acid change which affects MTHFR enzyme activity and can increase homocysteine, a vascular disease risk factor. This polymorphism was examined for association with stroke. In a case-control study of 241 ischemic stroke patients and 304 controls in Hong Kong, the V allele increased in stroke [28% vs. 20%, odds ratio (OR) 1.5, p=0.003]. A lack of significance for the increase in the VV genotype (7.5% vs. 4.6%, OR 1.7, p=0.16) may be due to its rarity in this region. V-allele carriers had more severe strokes (according to the NIH stroke scale). The association of the V allele with stroke occurred mostly in women or older subjects and was due to decreasing V allele frequency with age, as seen in other studies. This V frequency decline with age might be due to a loss of V-carrying controls from a higher risk of cancer, vascular disease, bone fracture, and kidney failure when folate is sparse. Examination of previous studies revealed that the association of VV genotype with stroke appeared stronger in Japan than elsewhere, possibly due to dietary differences. Perhaps folate supplementation for stroke prevention would particularly benefit VV individuals in such high-risk regions.
著者Baum L, Wong KS, Ng HK, Tomlinson B, Rainer TH, Chan DKY, Thomas GN, Chen XY, Poon P, Cheung WS, Woo KS
期刊名稱Clinical Chemistry and Laboratory Medicine
出版年份2004
月份1
日期1
卷號42
期次12
出版社WALTER DE GRUYTER & CO
頁次1370 - 1376
國際標準期刊號1434-6621
電子國際標準期刊號1437-4331
語言英式英語
關鍵詞elderly; folate; methylenetetrahydrofolate reductase (MTHFR); mutation; polymorphism; stroke
Web of Science 學科類別Medical Laboratory Technology; MEDICAL LABORATORY TECHNOLOGY

上次更新時間 2021-15-01 於 00:43