Increased Cognitive Control During Execution of Finger Tap Movement in People with Parkinson's Disease
Publication in refereed journal


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摘要Background: Previous studies employed demanding and complex hand tasks to study the brain activation in people with Parkinson’s Disease (PD). There is inconsistent finding about the cerebellar activity during movement execution of this patient population.

Objectives: This study aimed to examine the brain activation patterns of PD individuals in the on-state and healthy control subjects in a simple finger tapping task.

Methods: Twenty-seven patients with PD and 22 age-matched healthy subjects were recruited for the study. Subjects were instructed to perform simple finger tapping tasks under self- and cue-initiated conditions in separate runs while their brain activations were captured using fMRI.

Results: Healthy subjects had higher brain activity in contralateral precentral gyrus during the self-initiated task, and higher brain activity in the ipsilateral middle occipital gyrus during the cue-initiated task. PD patients had higher brain activity in the cerebellum Crus I (bilateral) and lobules VI (ipsilateral) during the self-initiated task and higher brain activity in the contralateral middle frontal gyrus during the cue-initiated task. When compared with healthy controls, PD patients had lower brain activity in the contralateral inferior parietal lobule during the self-initiated task, and lower brain activity in the ipsilateral cerebellum lobule VIII, lobule VIIB and vermis VIII, and thalamus during the cue-initiated task. Conjunction analysis indicated that both groups had activation in bilateral cerebellum and SMA and ipsilateral precentral gyrus and postcentral gyrus during both self- and cue-initiated movement. Individuals with PD exhibited higher brain activity in the executive zone (cerebellum Crus I and II) during self-initiated movement, and lower brain activity in the sensorimotor zone (i.e. lobule VIIb and VIII of the cerebellum) during cue-initiated movement.

Discussions: The findings suggest that individuals with PD may use more executive control when performing simple movements.
著者Mak MKY, Cheung V, Ma SY, Lu ZL, Wang DF, Lou WT, Shi L, Mok VCT, Chu WCW, Hallett M
期刊名稱Journal of Parkinson's Disease
出版年份2016
月份8
日期20
卷號6
期次3
出版社IOS PRESS
頁次639 - 650
國際標準期刊號1877-7171
電子國際標準期刊號1877-718X
語言英式英語
關鍵詞Cerebellum; cognition; fMRI; movement disorders; Parkinson's disease
Web of Science 學科類別Neurosciences; Neurosciences & Neurology

上次更新時間 2021-28-02 於 01:35