An unexpected Bromolactamization of Olefinic Amides Using a Three-Component Co-catalyst System
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AbstractReaction between (N,N-dimethylamino)pyridine and isocyanate unexpectedly produced a three-component mixture. By using this mixture as an unprecedented three-component catalyst system, a facile and selective bromolactamization of olefinic amides has been developed. The protocol confers enhanced selectivity of N- over O-cyclization, leading to the formation of a structurally diverse range of lactams including both small and medium ring sizes.
All Author(s) ListCheng YA, Yu WZR, Yeung YY
Journal nameJournal of Organic Chemistry
Year2016
Month1
Day15
Volume Number81
Issue Number2
PublisherAMER CHEMICAL SOC
Pages545 - 552
ISSN0022-3263
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesChemistry; Chemistry, Organic

Last updated on 2020-25-10 at 01:52