Expression of nm23-H1 in human meningioma cells
Publication in refereed journal

香港中文大學研究人員

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摘要The expression of nm23-H1 has been demonstrated to be highly correlated with the metastatic potential of various tumors. In the present investigation, meningiomas of different pathological grades were used to study on their nm23-H1 expression. Immunohistochemistry showed that nm23-H1 was expressed mainly in the cytoplasm especially in the perinuclear region in explants under short-term culture. Western-blotting demonstrated the specific expression of nm23 protein in all tumor samples. The expression was also found to be sex-dependent on tumor progression in female, but not in male patients. RT-PCR result confirmed nm23-H1 expression was higher in benign tumors than in their normal counterpart. Our observations thus suggest that nm23-H1 may play an important role in the progression of meningiomas in female patients.
著者Wang SW, Yam HF, Yang L, Ng HK, Wang SL, Wu BQ, Wang ZH, ChewCheng SB, Chew EC
期刊名稱Anticancer Research
出版年份1997
月份9
日期1
卷號17
期次5A
出版社INT INST ANTICANCER RESEARCH
頁次3569 - 3573
國際標準期刊號0250-7005
電子國際標準期刊號1791-7530
語言英式英語
關鍵詞meningioma; metastatic suppressor gene and metastasis; nm23
Web of Science 學科類別Oncology; ONCOLOGY

上次更新時間 2021-03-03 於 01:38