Computer-controlled infusion of propofol for long neurosurgical procedures
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AbstractThis study evaluated the performance of a computer-controlled infusion (CCI) system for propofol during long neurosurgical procedures. Anesthesia was induced and maintained in 15 patients using a CCI of propofol. The initial target concentration was set at 3 mu g/ml, and this was then titrated according to the clinical situation. A total of 284 blood samples were taken for propofol assay. The performance of the system during anesthesia, assessed using the median performance error(MDPE), median absolute performance error (MDAPE), wobble, and divergence, were -5.3%, 20.6%, 9.0%, and 0.3%h, respectively. MDPE and MDAPE during the first: 20 min after stopping the infusion were -38.7% and 39.0%, respectively. The CCI system did not show significant changes in predictive ability, with time during anesthesia lasting up to 12 h. Changes in the measured blood concentration were in the same direction as changes in the target concentration.
All Author(s) ListLim TA, Gin T, Tam YH, Aun CST, Short TG
Journal nameJournal of Neurosurgical Anesthesiology
Volume Number9
Issue Number3
Pages242 - 249
LanguagesEnglish-United Kingdom
Keywordscomputer-controlled infusion; pharmacokinetics; propofol
Web of Science Subject CategoriesAnesthesiology; ANESTHESIOLOGY; Clinical Neurology; CLINICAL NEUROLOGY; Neurosciences & Neurology; Surgery; SURGERY

Last updated on 2020-23-11 at 01:12