Computer-controlled infusion of propofol for long neurosurgical procedures
Publication in refereed journal

香港中文大學研究人員

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摘要This study evaluated the performance of a computer-controlled infusion (CCI) system for propofol during long neurosurgical procedures. Anesthesia was induced and maintained in 15 patients using a CCI of propofol. The initial target concentration was set at 3 mu g/ml, and this was then titrated according to the clinical situation. A total of 284 blood samples were taken for propofol assay. The performance of the system during anesthesia, assessed using the median performance error(MDPE), median absolute performance error (MDAPE), wobble, and divergence, were -5.3%, 20.6%, 9.0%, and 0.3%h, respectively. MDPE and MDAPE during the first: 20 min after stopping the infusion were -38.7% and 39.0%, respectively. The CCI system did not show significant changes in predictive ability, with time during anesthesia lasting up to 12 h. Changes in the measured blood concentration were in the same direction as changes in the target concentration.
著者Lim TA, Gin T, Tam YH, Aun CST, Short TG
期刊名稱Journal of Neurosurgical Anesthesiology
出版年份1997
月份7
日期1
卷號9
期次3
出版社LIPPINCOTT-RAVEN PUBL
頁次242 - 249
國際標準期刊號0898-4921
語言英式英語
關鍵詞computer-controlled infusion; pharmacokinetics; propofol
Web of Science 學科類別Anesthesiology; ANESTHESIOLOGY; Clinical Neurology; CLINICAL NEUROLOGY; Neurosciences & Neurology; Surgery; SURGERY

上次更新時間 2020-22-10 於 00:53