Increases in mRNA levels of glucose transporters types 1 and 3 in Ehrlich ascites tumor cells during tumor development
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摘要A common feature of many tumors is an increase in glucose catabolism during tumor growth. We studied the mechanism of this phenomenon by using Ehrlich ascites tumor bearing mice as the animal model. We found that Ehrlich ascites tumor ce Is possess only glucose transporter 1 (GLUT1) and GLUT3 but no GLUT2, GLUT4, or GLUT5. The mRNA levels of GLUT1 and GLUT3 increased progressively in the tumour during development; however, there were no changes observable in mRNA levels of glucose transporters of all types in brain, liver, and heart of the host mice. These findings suggest that Ehrlich ascites tumor augments its glucose transport mechanism relative to other tissues in response to its unique growth needs. (C) 1997 Wiley-Liss, Inc.
著者Au KK, Liong E, Li JY, Li PS, Liew CC, Kwok TT, Choy YM, Lee CY, Fung KP
期刊名稱Journal of Cellular Biochemistry
出版年份1997
月份10
日期1
卷號67
期次1
出版社WILEY-LISS
頁次131 - 135
國際標準期刊號0730-2312
電子國際標準期刊號1097-4644
語言英式英語
關鍵詞Ehrlich ascites tumor; glucose transporter; mRNA
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Cell Biology; CELL BIOLOGY

上次更新時間 2020-01-08 於 02:16