Aerosol delivery to non-ventilated infants by metered dose inhaler: Should a valved spacer be used?
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摘要In a randomized double-blind cross-over study on 20 spontaneously breathing, oxygen-dependent preterm infants who had received positive pressure ventilation for respiratory distress syndrome, we tested the hypothesis that the one-way non-rebreathing valves of aerosol spacer devices might impair rather than enhance the delivery of aerosols to small infants by metered dose inhalers (MDI). Ten infants were given 2 doses (200 mu g/dose) of MDI albuterol through a neonatal Aerochamber(R) 4 h apart. At tandem sequence, one dose was delivered with the non-rebreathing Valve of the Aerochamber(R) place; for the other dose, the valve had been removed. The experiment was repeated on another ten infants using a different spacer device (Babyhaler(R)) with or without its one-way inspiratory valve removed.
著者Fok TF, Lam K, Chan CK, Ng PC, Zhuang H, Wong W, Cheung KL
期刊名稱Pediatric Pulmonology
出版年份1997
月份9
日期1
卷號24
期次3
出版社WILEY-LISS
頁次204 - 212
國際標準期刊號8755-6863
電子國際標準期刊號1099-0496
語言英式英語
關鍵詞albuterol; bronchopulmonary dysplasia; infant pulmonary function; metered dose inhalers; spacers
Web of Science 學科類別Pediatrics; PEDIATRICS; Respiratory System; RESPIRATORY SYSTEM

上次更新時間 2020-21-09 於 01:43