Differential effects of pinacidil, cromakalim, and NS 1619 on electrically evoked contractions in rat vas deferens
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香港中文大學研究人員

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摘要AIM: To compare the inhibitory action of electrically evoked contractions of rat epididymal vas deferens by pinacidil (Pin), cromakalim (Cro), and NS 1619. METHODS: Monophasic contractions were evoked by electric field stimulation in rat isolated epididymal half of vas deferens. RESULTS: Newly developed ATP-sensitive K+ channel openers, Pin and Cro, concentration-dependently reduced the electrically evoked (0.3 Hz, 1 ms pulse duration, 60 V) contractions and glibenclamide but not charybdotoxin antagonized the inhibitory effects of both agents. Pin shifted the concentration-response curve for norepinephrine to the right with reducing the magnitude of the maximum contraction in a glibenclamid-sensitive fashion. The large-conductance Ca2+-activated K+ channel opener, NS 1619, inhibited the electrically evoked contractions in a concentration-dependent manner. Charybdotoxin (100 nmol.L-1) partially reduced the effect of NS 1619 but glibenclamide (10 mu mol.L-1) showed no effect. None of these 3 agents affected the basal tension. Both ATP-sensitive and Ca2+-activated K+ channels presented in vas deferens smooth muscles involved in regulation of muscle contractility.
著者Huang Y, Lau CW
期刊名稱ACTA PHARMACOLOGICA SINICA
出版年份1997
月份7
日期1
卷號18
期次4
出版社ACTA PHARMACOLOGICA SINICA
頁次293 - 298
國際標準期刊號0253-9756
語言英式英語
關鍵詞charybdotoxin; cromakalim; electric stimulation; glyburide; muscle contraction; NS 1619; pinacidil; potassium channels; vas deferens
Web of Science 學科類別Chemistry; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

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