Angiotensin II receptors, AT(1) and AT(2) in the rat epididymis immunocytochemical and electrophysiological studies
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摘要Previous work from our laboratory has provided evidence for the presence of a tissue renin-angiotensin system in the rat epididymis. In the current investigation, the regional localization of angiotensin II receptors, type I (AT(1)) and type II (AT(2)) was studied immunocytochemically using specific anti-peptide antibodies against the second extracellular loops of AT(1) and AT(2) receptors, and pharmacologically using specific receptor antagonists in conjunction with the short-circuit current technique, The immunocytochemical results showed that AT(1) and AT(2) immunoreactivities were predominantly localized in the basal region of the epididymal epithelium. Electrophysiological studies using the short-circuit current technique demonstrated a stimulatory effect of basolaterally applied angiotensin II on the epididymal electrogenic ion transport. This effect was inhibitable by the addition of AT(1) antagonist, losartan but not by AT(2) antagonist, PD123177, indicating a functional role of AT(1) in epididymal electrolyte transport. The present finding suggests that angiotensin II receptors may play an important role in the regulation of epididymal function.
著者Leung PS, Chan HC, Fu LXM, Zhou WL, Wong PYD
期刊名稱Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
出版年份1997
月份6
日期5
卷號1357
期次1
出版社ELSEVIER SCIENCE BV
頁次65 - 72
國際標準期刊號0167-4889
電子國際標準期刊號0006-3002
語言英式英語
關鍵詞(rat); angiotensin II; angiotensin II receptor; electrophysiology; epididymis; epithelium; immunocytochemistry
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Cell Biology; CELL BIOLOGY

上次更新時間 2021-26-02 於 02:06