Evaluation of artificial skin (Integra) in a rodent model
Publication in refereed journal


全文

引用次數

其它資訊
摘要The biocompatibility of artificial skin (Integra) has been investigated in clean surgical wounds of 20 guinea-pigs. A rectangular 3 x 3 cm full-thickness skin deject with excision carried down to the panniculus carnosus was prepared on the dorsal area of the guinea-pig. A thin layer of saver sulfadiazine cream was applied and artificial skin was placed to cover the wound. At clay 14, the uppermost silicone layer was removed. Good take of the artificial skin was observed in 18 of 20 animals. Microscopy showed good vascular ingrowth in 14 of the 18 animals. The remaining four animals showed necrotic tissue, absence of vascularization and haemorrhage in the wound bed. Two of the 20 wounds showed purulent discharge. In this animal model, clinical 'take' of the neodermis was achieved in 18/20 animals (90 per cent), while vascular ingrowth was observed in only 14/20 animals (70 per cent). These results suggested that artificial skin in clean surgical wound is readily biologically incorporated into surrounding viable tissue. (C) 1997 Elsevier Science Ltd for ISBI.
著者King WWK, Lam PK, Liew CT, Ho WS, Li AKC
會議名稱2nd Asian/Pacific Burns Conference
會議開始日08.02.1996
會議完結日11.02.1996
會議地點HONG KONG
期刊名稱Burns
出版年份1997
月份3
日期1
卷號23
出版社ELSEVIER SCI LTD
頁次S30 - S32
國際標準期刊號0305-4179
語言英式英語
Web of Science 學科類別Critical Care Medicine; CRITICAL CARE MEDICINE; Dermatology; DERMATOLOGY; General & Internal Medicine; Surgery; SURGERY

上次更新時間 2021-28-02 於 01:30