A comparison of human immunodeficiency virus type 1 inhibition by partially purified aqueous extracts of Chinese medicinal herbs
Publication in refereed journal


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替代計量分析
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摘要A multiple screening approach to detect compounds inhibitory to various aspects of the human immunodeficiency virus type 1 (HIV-1) life-cycle has been applied to aqueous extracts of 19 herbs traditionally used in Chinese medicine as anti-viral agents. The extracts were tested for their ability to inhibit HIV-1 in a series of in vitro assays. The extracts were tested for inhibition of the interaction between HIV-1 gp120 and immobilized CD4 receptor, inhibition of recombinant HIV-1 reverse transcriptase and for inhibition of three glycohydrolase enzymes that contribute to viral protein glycosylation. Six of the herb extracts (30%) were potent inhibitors of the interaction between HIV-1 gp120 and the CD4 receptor (ID50 5.6 - 79.4 mu g/ml), two extracts (10%) contained potent reverse transcriptase inhibitors (ID50 16.9 - 26.0 mu g/ml) and 14 extracts (75%) were able to inhibit at least one of the glycohydrolase enzymes. (C) 1997 Elsevier Science Inc.
著者Collins RA, Ng TB, Fong WP, Wan CC, Yeung HW
期刊名稱Life Sciences
出版年份1997
月份5
日期2
卷號60
期次23
出版社PERGAMON-ELSEVIER SCIENCE LTD
頁次PL345 - PL351
國際標準期刊號0024-3205
電子國際標準期刊號1879-0631
語言英式英語
關鍵詞CD4-gp120 interaction; Chinese medicinal herbs; glycohydrolase enzymes; HIV-1 reverse transcriptase
Web of Science 學科類別Medicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Research & Experimental Medicine

上次更新時間 2020-26-10 於 02:21