A comparison of human immunodeficiency virus type 1 inhibition by partially purified aqueous extracts of Chinese medicinal herbs
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AbstractA multiple screening approach to detect compounds inhibitory to various aspects of the human immunodeficiency virus type 1 (HIV-1) life-cycle has been applied to aqueous extracts of 19 herbs traditionally used in Chinese medicine as anti-viral agents. The extracts were tested for their ability to inhibit HIV-1 in a series of in vitro assays. The extracts were tested for inhibition of the interaction between HIV-1 gp120 and immobilized CD4 receptor, inhibition of recombinant HIV-1 reverse transcriptase and for inhibition of three glycohydrolase enzymes that contribute to viral protein glycosylation. Six of the herb extracts (30%) were potent inhibitors of the interaction between HIV-1 gp120 and the CD4 receptor (ID50 5.6 - 79.4 mu g/ml), two extracts (10%) contained potent reverse transcriptase inhibitors (ID50 16.9 - 26.0 mu g/ml) and 14 extracts (75%) were able to inhibit at least one of the glycohydrolase enzymes. (C) 1997 Elsevier Science Inc.
All Author(s) ListCollins RA, Ng TB, Fong WP, Wan CC, Yeung HW
Journal nameLife Sciences
Volume Number60
Issue Number23
PagesPL345 - PL351
LanguagesEnglish-United Kingdom
KeywordsCD4-gp120 interaction; Chinese medicinal herbs; glycohydrolase enzymes; HIV-1 reverse transcriptase
Web of Science Subject CategoriesMedicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Research & Experimental Medicine

Last updated on 2020-15-09 at 00:52