Actions of lectins from the mushroom Tricholoma mongolicum on macrophages, splenocytes and life-span in sarcoma-bearing mice
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AbstractTwo lectins isolated from the mushroom Tricholoma mongolicum stimulated the production of nitrite ions by macrophages in normal and tumor-bearing mice. Both lectins exhibited negligible mitogenic activity toward T-cells or splenocytes from normal mice in vitro when compared with Con A. Similarly, T-cells from sarcoma-bearing mice treated with the lectins did not exhibit a mitogenic response different from that of the control. However, T-cells from normal lectin-treated mice demonstrated a reduced mitogenic response when compared with the control. In mice the growth of sarcoma 180 cells in the peritoneal cavity was inhibited and the life-span was prolonged by the two lectins.
All Author(s) ListWang HX, Ng TB, Ooi VEC, Liu WK, Chang ST
Journal nameAnticancer Research
Volume Number17
Issue Number1A
Pages419 - 424
LanguagesEnglish-United Kingdom
Keywordsantitumor activity; immunomodulation; lectin; mitogenic response; Tricholoma mongolicum
Web of Science Subject CategoriesOncology; ONCOLOGY

Last updated on 2022-11-01 at 00:19