Actions of lectins from the mushroom Tricholoma mongolicum on macrophages, splenocytes and life-span in sarcoma-bearing mice
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AbstractTwo lectins isolated from the mushroom Tricholoma mongolicum stimulated the production of nitrite ions by macrophages in normal and tumor-bearing mice. Both lectins exhibited negligible mitogenic activity toward T-cells or splenocytes from normal mice in vitro when compared with Con A. Similarly, T-cells from sarcoma-bearing mice treated with the lectins did not exhibit a mitogenic response different from that of the control. However, T-cells from normal lectin-treated mice demonstrated a reduced mitogenic response when compared with the control. In mice the growth of sarcoma 180 cells in the peritoneal cavity was inhibited and the life-span was prolonged by the two lectins.
All Author(s) ListWang HX, Ng TB, Ooi VEC, Liu WK, Chang ST
Journal nameAnticancer Research
Year1997
Month1
Day1
Volume Number17
Issue Number1A
PublisherINT INST ANTICANCER RESEARCH
Pages419 - 424
ISSN0250-7005
eISSN1791-7530
LanguagesEnglish-United Kingdom
Keywordsantitumor activity; immunomodulation; lectin; mitogenic response; Tricholoma mongolicum
Web of Science Subject CategoriesOncology; ONCOLOGY

Last updated on 2020-26-09 at 02:39