The isolation and characterization of an immunomodulatory and anti-tumor polysaccharide preparation from Flammulina velutipes
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摘要Alkaline-soluble antitumor polysaccharide was prepared from the cell wall of the mushroom Flammulina velutipes. The backbone(s) of the polysaccharide is mainly composed of beta-(1-->,3)-D-linked glucose and its molecular weight was estimated to be about 200 kD. The polysaccharide was found to be non-toxic by brine shrimp assay. When injected into mice intraperitoneally, the polysaccharide triggered proliferation of splenic lymphocytes and also vascular dilation and hemorrhage (VDH) response. The polysaccharide exhibited potent anti-tumor activity against sarcoma SC-180 in vivo but not in vitro.
著者Leung MYK, Fung KP, Choy YM
期刊名稱IMMUNOPHARMACOLOGY
出版年份1997
月份1
日期1
卷號35
期次3
出版社ELSEVIER SCIENCE BV
頁次255 - 263
國際標準期刊號0162-3109
語言英式英語
關鍵詞anti-tumor polysaccharide; Flammulina velutipes; immunostimulation; mushroom
Web of Science 學科類別Immunology; Pharmacology & Pharmacy

上次更新時間 2020-06-08 於 02:18