The isolation and characterization of an immunomodulatory and anti-tumor polysaccharide preparation from Flammulina velutipes
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AbstractAlkaline-soluble antitumor polysaccharide was prepared from the cell wall of the mushroom Flammulina velutipes. The backbone(s) of the polysaccharide is mainly composed of beta-(1-->,3)-D-linked glucose and its molecular weight was estimated to be about 200 kD. The polysaccharide was found to be non-toxic by brine shrimp assay. When injected into mice intraperitoneally, the polysaccharide triggered proliferation of splenic lymphocytes and also vascular dilation and hemorrhage (VDH) response. The polysaccharide exhibited potent anti-tumor activity against sarcoma SC-180 in vivo but not in vitro.
All Author(s) ListLeung MYK, Fung KP, Choy YM
Journal nameIMMUNOPHARMACOLOGY
Year1997
Month1
Day1
Volume Number35
Issue Number3
PublisherELSEVIER SCIENCE BV
Pages255 - 263
ISSN0162-3109
LanguagesEnglish-United Kingdom
Keywordsanti-tumor polysaccharide; Flammulina velutipes; immunostimulation; mushroom
Web of Science Subject CategoriesImmunology; Pharmacology & Pharmacy

Last updated on 2020-13-07 at 02:25