A randomized, double-blind, placebo-controlled, crossover study on the effect of oral oestradiol on acute menopausal symptoms
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AbstractAcute menopausal symptoms occur less frequently in Asian than in Caucasian women. Oestrogen replacement therapy has been shown to be effective in controlling acute symptoms in Caucasians, but the effect of oestrogens is not well documented in Asian women. A randomized, double-blind, placebo-controlled, crossover study of the effect of oral oestradiol on the incidence of acute menopausal symptoms was conducted in 83 Hong Kong Chinese women who had experienced a surgical menopause. Although there was a significant increase in the oestradiol concentration with treatment compared with placebo (P < 0.001), there were no significant differences in the reporting of symptoms between the treatment and placebo groups. There is no obvious explanation for this apparent lack of effect of oestrogen on acute menopausal symptoms in Chinese women. Whilst it may be related to the generally low incidence of symptoms or to a higher dietary intake of phytoestrogens in Chinese women, further studies are necessary to explain these findings.
All Author(s) ListChung TKH, Yip SK, Lam P, Chang AMZ, Haines CJ
Journal nameMaturitas
Volume Number25
Issue Number2
Pages115 - 123
LanguagesEnglish-United Kingdom
Keywordsacute menopausal symptoms; Hong Kong Chinese women; oral oestradiol
Web of Science Subject CategoriesGeriatrics & Gerontology; GERIATRICS & GERONTOLOGY; Obstetrics & Gynecology; OBSTETRICS & GYNECOLOGY

Last updated on 2020-12-08 at 23:24