Fatal haemorrhagic gastritis associated with oral sulindac treatment for patent ductus arteriosus
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摘要We report the first case in a preterm infant given oral sulindac for treatment of symptomatic patent ductus arteriosus who subsequently developed severe acute haemorrhagic gastritis leading to disseminated intravascular coagulation, massive pulmonary haemorrhage and death. The postmortem examination suggested that the mechanism was likely a direct irritant insult causing ischaemia on the gastric mucosa. Although sulindac is supposed to be a renal-sparing non-steroidal anti-inflammatory prodrug associated with minimal renal and gastrointestinal adverse effects, clinicans should be alerted to this potential life-threatening complication in preterm infants. Until the question of safety could be adequately addressed, the use of sulindac for ductal closure should remain experimental.
著者Ng PC, So KW, Fok TF, To KF, Wong W, Liu K
期刊名稱Acta Paediatrica
出版年份1996
月份7
日期1
卷號85
期次7
出版社SCANDINAVIAN UNIVERSITY PRESS
頁次884 - 886
國際標準期刊號0803-5253
語言英式英語
關鍵詞gastritis; patent ductus arteriosus; preterm; sulindac
Web of Science 學科類別Pediatrics; PEDIATRICS

上次更新時間 2020-17-10 於 00:18