Fatal haemorrhagic gastritis associated with oral sulindac treatment for patent ductus arteriosus
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AbstractWe report the first case in a preterm infant given oral sulindac for treatment of symptomatic patent ductus arteriosus who subsequently developed severe acute haemorrhagic gastritis leading to disseminated intravascular coagulation, massive pulmonary haemorrhage and death. The postmortem examination suggested that the mechanism was likely a direct irritant insult causing ischaemia on the gastric mucosa. Although sulindac is supposed to be a renal-sparing non-steroidal anti-inflammatory prodrug associated with minimal renal and gastrointestinal adverse effects, clinicans should be alerted to this potential life-threatening complication in preterm infants. Until the question of safety could be adequately addressed, the use of sulindac for ductal closure should remain experimental.
All Author(s) ListNg PC, So KW, Fok TF, To KF, Wong W, Liu K
Journal nameActa Paediatrica
Volume Number85
Issue Number7
Pages884 - 886
LanguagesEnglish-United Kingdom
Keywordsgastritis; patent ductus arteriosus; preterm; sulindac
Web of Science Subject CategoriesPediatrics; PEDIATRICS

Last updated on 2021-24-09 at 01:15