Identification of two prolactin cDNA sequences from a goldfish pituitary cDNA library
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AbstractWe have identified two different cDNA clones encoding for goldfish prolactin (gfPRL) from a pituitary cDNA library, The coding regions of these clones are predicted to encode for an identical amino acid (aa) sequence with four silent mutations. The 3'-untranslated regions (UTRs) of these clones show only 72% nucleotide (nt) sequence identity. The two genes each encoding gfPRL might have derived from recent gene duplication before the divergence of goldfish from other Cypriniforms. Genomic Southern blot analysis of goldfish DNA also demonstrated that there is a small family of two genes for prolactin in the genome of goldfish.
All Author(s) ListChan YH, Cheng KW, Yu KL, Chan KM
Journal nameBBA - Gene Structure and Expression
Volume Number1307
Issue Number1
Pages8 - 12
LanguagesEnglish-United Kingdom
KeywordscDNA cloning; gene evolution; nucleotide sequence; pituitary hormone; teleost
Web of Science Subject CategoriesBiochemistry & Molecular Biology; Biophysics

Last updated on 2020-27-10 at 02:44