Varicella exposure in a neonatal intensive care unit: Emergency management and control measures
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摘要We describe an exposure of varicella tester virus in our neonatal intensive-care unit and the emergency procedures instituted to prevent an outbreak. Fifty-seven infants and 129 staff members were exposed but none developed chickenpox. The measures included rapid identification of varicella antibody status in all neonates and those staff members with uncertain history of varicella infection; cohorting of exposed infants according to immune status; and prompt administration of varicella tester immunoglobulin to susceptible patients. The recommendations of the American Academy of Pediatrics did not accurately predict the immune status of preterm infants, as only one of the eight susceptible infants would have qualified for immunoglobulin prophylaxis if their guidelines had been followed. Mass screening of all exposed infants using the varicella tester enzyme linked immunosorbent assay (ELISA) test was the only reliable means of determining the immune status. Of the four risk factors evaluated for the prediction of antibody status: gestational age, postnatal age, birthweight and episodes of blood transfusion, only postnatal age was found to independently predict the immune status of our patients. Because varicella tester susceptible staff members are difficult to identify on the basis of history, we suggest that prospective screening of staff in high-risk units be undertaken and vaccination with live varicella vaccine be offered to susceptibles.
著者Ng PC, Lyon DJ, Wong MY, Fok TF, Wong W, Cheung KL, Tam JS, Cheng AFB
期刊名稱Journal of Hospital Infection
出版年份1996
月份3
日期1
卷號32
期次3
出版社W B SAUNDERS CO LTD
頁次229 - 236
國際標準期刊號0195-6701
電子國際標準期刊號1532-2939
語言英式英語
關鍵詞control measures; immunoglobulin; newborns; varicella zoster
Web of Science 學科類別Infectious Diseases; INFECTIOUS DISEASES

上次更新時間 2020-27-10 於 02:42