Effect of methotrexate on the intracellular phosphoribosyl pyrophosphate level and glucose transport of Ehrlich ascites tumor cells in vitro
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摘要Methotrexate (MTX) suppressed the growth of Ehrlich ascites tumor (EAT) cells in vitro. The intracellular level of phosphoribosyl 5-pyrophosphate (PRPP) of EAT cells increased in a dose-dependent manner in response to MTX treatment. At the same time, the rate of glucose transport was lowered. Hypoxanthine reversed both these effects of MTX and partially rescued EAT cell growth. Under all conditions tested, changes in rate of glucose transport were shown to be the result of alterations in the number of glucose transporter (V-max) rather than ligand affinity (K-m). The dual action of MTX as a chemotherapeutic agent is discussed in this light.
著者Fung KP, Lam WP, Choy YM, Lee CY
期刊名稱Oncology
出版年份1996
月份1
日期1
卷號53
期次1
出版社KARGER
頁次27 - 30
國際標準期刊號0030-2414
語言英式英語
關鍵詞Ehrlich ascites; glucose transporter; methotrexate; phosphoribosyl phosphate; tumor
Web of Science 學科類別Oncology; ONCOLOGY

上次更新時間 2020-04-08 於 04:34