K1 and K3 capsular antigens of Klebsiella induce tumor necrosis factor activities
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AbstractCapsular polysaccharide antigens isolated from Klebsiella pneumoniae sere-type 1 (K1) and sere-type 3 (K3) could induce tumor necrosis factor-alpha in ICR mice. K1 and K3 capsular antigens were found to be non-toxic by brine shrimp bioassay. When injected into Ehrlich ascites tumor-bearing mice, both K1 and K3 capsular antigens exhibited significant suppression in the growth of tumor cells. The significance of these observations is discussed.
All Author(s) ListChoy YM, Tsang SF, Kong SK, Leung KN, Parolis H, Lee CY, Fung KP
Journal nameLife Sciences
Volume Number58
Issue Number9
LanguagesEnglish-United Kingdom
KeywordsK1 and K3 capsular antigens; Klebsiella pneumoniae; tumor necrosis factor-alpha
Web of Science Subject CategoriesMedicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Research & Experimental Medicine

Last updated on 2020-05-07 at 01:49