ENDOGENOUS PRODUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA IN COMBINATION WITH HYPERTHERMIA FOR THE TREATMENT OF MICE BEARING EHRLICH ASCITES TUMOR
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AbstractMultiple hyperthermia was found to exert an additive antitumor effect when combined with the in vivo production of tumor necrosis factor alpha (TNF-alpha) in mice bearing Ehrlich ascites tumor (EAT). TNF-alpha was produced in EAT-bearing mice by priming the animals with zymosan and subsequently challenging with lipopolysaccharide (LPS). Mice were pretreated with sulindac and D-mannoheptulose to alleviate the toxic side effects of LPS. While the ability of these tumor-bearing mice to produce TNF-alpha remained unchanged under hyperthermia, the EAT cell number was suppressed in the combined-treatment group compared with groups treated with TNF-alpha or hyperthermia alone. In the same comparison, the life span of EAT-bearing mice in the combined-treatment group was prolonged.
All Author(s) ListWONG CK, FUNG KP, KONG SK, LEE CY, CHOY YM
Journal nameChemotherapy
Year1995
Month9
Day1
Volume Number41
Issue Number5
PublisherKARGER
Pages378 - 383
ISSN0009-3157
LanguagesEnglish-United Kingdom
KeywordsEHRLICH ASCITES TUMOR; HYPERTHERMIA; TUMOR NECROSIS FACTOR ALPHA
Web of Science Subject CategoriesOncology; ONCOLOGY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-05-07 at 01:49