EXAMINATION FOR TOXICITY OF A CHINESE DRUG, THE TOAD GLANDULAR SECRETORY PRODUCT CHAN SU, IN PREGNANT MICE AND EMBRYOS
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摘要In order to evaluate the developmental toxicity and teratogenicity of a Chinese drug, the toad venom Chan Su, the drug was administered in a single intraperitoneal injection to pregnant ICR mice during the period of embryonic organogenesis. At the end of the gestation period, the mice were sacrificed, and the fetuses were collected, fixed and sectioned. A dose of Chan Su lower than 50 mg (dry weight)/kg body weight did not produce detectable changes in the recipient mice, but at a dose of 50 mg/kg the drug induced a decrease in body weight and structural abnormalities in livers and kidneys of the pregnant mice as well as increases in the number of resorbed and dead fetuses. There was a reduction in fetal weight although there were no changes in fetal crown-rump length nor tail length. No abnormalities were observed in the fetuses.
著者CHAN WY, NG TB, YEUNG HW
期刊名稱Biology of the Neonate
出版年份1995
月份5
日期1
卷號67
期次5
出版社KARGER
頁次376 - 380
國際標準期刊號0006-3126
語言英式英語
關鍵詞CHAN SU; PREGNANCY; TOAD GLANDULAR SECRETION; TOXICITY
Web of Science 學科類別Pediatrics

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