HUMAN TUMOR-NECROSIS-FACTOR-ALPHA INHIBITS GLUCOSE-TRANSPORT IN CULTURED EHRLICH ASCITES TUMOR-CELLS
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摘要Human recombinant tumour necrosis factor-alpha (rhTNF-alpha) arrested the growth of Ehrlich ascites tumour (EAT) cells in vitro. It suppressed cellular glucose uptake and decreased the membrane density of glucose transporters as measured by glucose-reversible cytochalasin B binding. The glucose transporters' affinity for substrate was also reduced. However, rhTNF-alpha treatment exerted no effect on the phosphoribosyl pyrophosphate level in EAT cells. The role of rhTNF-alpha on the inhibition of glucose transport of tumour cells is discussed.
著者FUNG KP, LAM WP, CHOY YM, LEE CY
期刊名稱Life Sciences
出版年份1995
月份5
日期26
卷號57
期次1
出版社PERGAMON-ELSEVIER SCIENCE LTD
國際標準期刊號0024-3205
電子國際標準期刊號1879-0631
語言英式英語
關鍵詞GLUCOSE TRANSPORT; TNF-ALPHA; TUMOR CELL
Web of Science 學科類別Medicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Research & Experimental Medicine

上次更新時間 2020-04-08 於 04:12