HUMAN TUMOR-NECROSIS-FACTOR-ALPHA INHIBITS GLUCOSE-TRANSPORT IN CULTURED EHRLICH ASCITES TUMOR-CELLS
Other outputs


Times Cited
Web of Science5WOS source URL (as at 29/05/2020) Click here for the latest count
Altmetrics Information
.

Other information
AbstractHuman recombinant tumour necrosis factor-alpha (rhTNF-alpha) arrested the growth of Ehrlich ascites tumour (EAT) cells in vitro. It suppressed cellular glucose uptake and decreased the membrane density of glucose transporters as measured by glucose-reversible cytochalasin B binding. The glucose transporters' affinity for substrate was also reduced. However, rhTNF-alpha treatment exerted no effect on the phosphoribosyl pyrophosphate level in EAT cells. The role of rhTNF-alpha on the inhibition of glucose transport of tumour cells is discussed.
All Author(s) ListFUNG KP, LAM WP, CHOY YM, LEE CY
Journal nameLife Sciences
Year1995
Month5
Day26
Volume Number57
Issue Number1
PublisherPERGAMON-ELSEVIER SCIENCE LTD
ISSN0024-3205
eISSN1879-0631
LanguagesEnglish-United Kingdom
KeywordsGLUCOSE TRANSPORT; TNF-ALPHA; TUMOR CELL
Web of Science Subject CategoriesMedicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Research & Experimental Medicine

Last updated on 2020-30-05 at 01:17