THE IMMUNOSTIMULATING ACTIVITIES OF ANTITUMOR POLYSACCHARIDES FROM PSEUDOSTELLARIA-HETEROPHYLLA
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摘要We have previously shown that a mitogenic fraction (PH-I) separated from Pseudostellaria heterophylla exhibits both immunomodulatory and anti-tumor activities. In the present study, PH-I was further purified by gel filtration chromatography and the resulting three fractions (PH-I A, PH-I B and PH-I C) were assessed for their anti-tumor activity in vivo. It was found that fraction PH-I C from P. heterophylla could markedly suppress the growth of EAT cells in vivo. Mechanistic studies have shown that i.p. injection of PH-I C into mice could enhance the phagocytic activity of thioglycollate-elicited peritoneal macrophages. Moreover, PH-I C showed a potent activating effect on the cytotoxic activity of natural killer (NK) cells and alloreactive cytotoxic T cells (Tc) as well as increased the MurIL-2-induced lymphokine activated killer cell (LAK) activity in vitro. In addition, PK-I C could increase the number of tumor infiltrating lymphocytes (TILs) in the tumor site of WEHI-164-bearing mice. Finally, i.v. injection of PH-I C significantly elevated the levels of IFN-gamma and IL-4 in sera of EAT-bearing mice.
著者WONG CK, LEUNG KN, FUNG KP, CHOY YM
期刊名稱IMMUNOPHARMACOLOGY
出版年份1994
月份7
日期1
卷號28
期次1
出版社ELSEVIER SCIENCE BV
頁次47 - 54
國際標準期刊號0162-3109
語言英式英語
關鍵詞ANTITUMOR POLYSACCHARIDE; IMMUNOSTIMULATION; PSEUDOSTELLARIA HETEROPHYLLA
Web of Science 學科類別Immunology; Pharmacology & Pharmacy

上次更新時間 2020-03-08 於 06:16