THE IMMUNOSTIMULATING ACTIVITIES OF ANTITUMOR POLYSACCHARIDES FROM PSEUDOSTELLARIA-HETEROPHYLLA
Publication in refereed journal


Times Cited
Web of Science35WOS source URL (as at 09/07/2020) Click here for the latest count
Altmetrics Information
.

Other information
AbstractWe have previously shown that a mitogenic fraction (PH-I) separated from Pseudostellaria heterophylla exhibits both immunomodulatory and anti-tumor activities. In the present study, PH-I was further purified by gel filtration chromatography and the resulting three fractions (PH-I A, PH-I B and PH-I C) were assessed for their anti-tumor activity in vivo. It was found that fraction PH-I C from P. heterophylla could markedly suppress the growth of EAT cells in vivo. Mechanistic studies have shown that i.p. injection of PH-I C into mice could enhance the phagocytic activity of thioglycollate-elicited peritoneal macrophages. Moreover, PH-I C showed a potent activating effect on the cytotoxic activity of natural killer (NK) cells and alloreactive cytotoxic T cells (Tc) as well as increased the MurIL-2-induced lymphokine activated killer cell (LAK) activity in vitro. In addition, PK-I C could increase the number of tumor infiltrating lymphocytes (TILs) in the tumor site of WEHI-164-bearing mice. Finally, i.v. injection of PH-I C significantly elevated the levels of IFN-gamma and IL-4 in sera of EAT-bearing mice.
All Author(s) ListWONG CK, LEUNG KN, FUNG KP, CHOY YM
Journal nameIMMUNOPHARMACOLOGY
Year1994
Month7
Day1
Volume Number28
Issue Number1
PublisherELSEVIER SCIENCE BV
Pages47 - 54
ISSN0162-3109
LanguagesEnglish-United Kingdom
KeywordsANTITUMOR POLYSACCHARIDE; IMMUNOSTIMULATION; PSEUDOSTELLARIA HETEROPHYLLA
Web of Science Subject CategoriesImmunology; Pharmacology & Pharmacy

Last updated on 2020-10-07 at 05:26