TUMOR-NECROSIS-FACTOR ELICITING FRACTIONS SEPARATED FROM PSEUDOSTELLARIA-HETEROPHYLLA
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摘要Tumor necrosis factor (TNF) could be induced in the serum of ICR mice bearing Ehrlich ascites tumor (EAT) cells by the i.v. administration of antitumor fractions (PH-I A, PH-I B, PH-I C, PH-I Ca, PH-I Cb) separated from the roots of Pseudostellaria heterophylla. TNF could also be detected in the ascitic fluid of EAT-bearing mice 2 h after i.v. injection with PH-I C, PH-I Ca or PH-I Cb. The proliferation of EAT cells was found to be significantly suppressed after the administration of these fractions. Our results suggest that the antitumor activity of P. heterophylla may be related, at least in part, to its capacity to induce TNF production in vivo. The strongest TNF eliciting and antitumor activity was found in the PH-I Cb fraction which is an acidic polysaccharide or proteoglycan with molecular weight of approximately 5000.
著者WONG CK, LEUNG KN, FUNG KP, PANG PKT, CHOY YM
期刊名稱INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY
出版年份1994
月份4
日期1
卷號16
期次4
出版社PERGAMON-ELSEVIER SCIENCE LTD
頁次271 - 277
國際標準期刊號0192-0561
語言英式英語
Web of Science 學科類別Immunology; Pharmacology & Pharmacy

上次更新時間 2020-08-08 於 02:33