A PROSPECTIVE EVALUATION OF PHARMACOKINETIC MODEL CONTROLLED INFUSION OF PROPOFOL IN PEDIATRIC-PATIENTS
Publication in refereed journal

香港中文大學研究人員

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摘要We have tested a published algorithm for pharmacokinetic model controlled infusion of propofol to supplement 67% nitrous oxide for general anaesthesia in Chinese children aged 4-10 yr. initially we studied 10 children undergoing minor procedures with spontaneous ventilation; mean duration of surgery was 38 min and mean propofol infusion rate 497 mu g kg(-1) min(-1). The precision of the model was 24.8% and bias -8.5%. The model was revised using an iterative linear least squares regression procedure and the revised model tested prospectively in another 20 children. The precision of the revised model was 21.5% (range in individuals 8.4-43.1%) and bias -0.1% (range -30 to 42%). Mean propofol infusion rate required to maintain anaesthesia was 474 mu g kg(-1) min(-1) (range 125-737 mu g kg(-1) min(-1)). The mean blood concentration required for satisfactory anaesthesia was 6.6 mu ml(-1) (range 3-11 mu g ml(-1)) and the mean blood concentration at the time of waking, which occurred 40 min after switching off the infusion, 0.86 mu g ml(-1) (range 0.40-1.45 mu g ml(-1)). Our patient population required different pharmacokinetic variables from those in the previous study. Recovery was slow because of the high infusion rates required to maintain satisfactory anaesthesia and large difference between She blood concentration required for anaesthesia and that at which waking occurred.
著者SHORT TG, AUN CST, TAN P, WONG J, TAM YH, OH TE
期刊名稱British Journal of Anaesthesia
出版年份1994
月份3
日期1
卷號72
期次3
出版社PROF SCI PUBL
頁次302 - 306
國際標準期刊號0007-0912
電子國際標準期刊號1471-6771
語言英式英語
關鍵詞ANESTHESIA, PEDIATRIC; ANESTHETICS, IV, PROPOFOL; PHARMACOKINETICS, MODELS
Web of Science 學科類別Anesthesiology; ANESTHESIOLOGY

上次更新時間 2020-16-10 於 02:43