EFFECTS OF PSEUDOSTELLARIA-HETEROPHYLLA ON PROLIFERATION AND DIFFERENTIATION OF MURINE BONE-MARROW CELLS
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AbstractThe incorporation of tritiated thymidine into the DNA of murine bone marrow cells could be stimulated by fraction PH-I Ba separated from the roofs of Pseudostellaria heterophylla in a dose-dependent manner in vitro. Moreover, PH-I Ba could induce the differentiation of murine bone marrow cells from pluripotent haemopoietic stem cells into macrophages-like cells in vitro. Autocrine or paracrine stimulation of granulocyte-macrophage colony stimulating factor was likely to underly the induction of differentiation. Therefore, PH-I Ba was proved to be an immunostimulating agent for mouse marrow hematopoiesis and was found to be a polysaccharide. The sugar components were analyzed by Gas Liquid Chromatography of their alditol acetates.
All Author(s) ListWONG CK, LEUNG KN, FUNG KP, CHOY YM
Journal nameImmunopharmacology and Immunotoxicology
Year1994
Month1
Day1
Volume Number16
Issue Number1
PublisherMARCEL DEKKER INC
Pages71 - 84
ISSN0892-3973
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesImmunology; IMMUNOLOGY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Toxicology; TOXICOLOGY

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