ONE-YEAR FOLLOW-UP OF DUODENAL-ULCERS AFTER 1-WK TRIPLE THERAPY FOR HELICOBACTER-PYLORI
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AbstractObjective: to study the ulcer recurrence rate of Helicobacter pylori-positive duodenal ulcers at 1 yr after eradication of the bacteria by triple therapy. Method: Patients with H. pylori-positive duodenal ulcers were randomized to receive either triple therapy for 1 wk plus omeprazole for 4 wk (Triple+OMP) (n = 78), or omeprazole alone (OMP) for 4 wk (N = 77). Patients were followed up every 3 months for symptom enquiry. At 1 yr, all asymptomatic patients were invited to attend for gastroscopy. Results: At 8 wk, 16 patients in the OMP group and four in the Triple+OMP group had an ulcer. During the l-yr period, 12 patients in the OMP group and no patient in the Triple+OMP group developed symptomatic ulcers. At follow-up endoscopy at 1 yr, another 10 ulcers were detected in the OMP group and two in the Triple+OMP group. Fifteen patients in the OMP group and 13 in the Triple+OMP group were lost to follow-up. In total, ulcers were detected in 39 of 61 (64%) assessable patients in the OMP group, and in six of 65 (9%) assessable patients in the Triple+OMP group after 1 yr (chi(2) test: p < 0.001). Of the patients whose H. pylori were successfully eradicated by Triple+OMP at 8 wk, 90% remained H. pylori negative at 1 yr. Conclusion: Triple therapy for 1 wk eradicates H. pylori infection and significantly reduces duodenal ulcer relapses.
All Author(s) ListSUNG JJY, CHUNG SCS, LING TKW, YUNG MY, CHENG AFB, HOSKING SW, LI AKC
Journal nameAmerican Journal of Gastroenterology
Year1994
Month2
Day1
Volume Number89
Issue Number2
PublisherWILLIAMS & WILKINS
Pages199 - 202
ISSN0002-9270
eISSN1572-0241
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesGastroenterology & Hepatology; GASTROENTEROLOGY & HEPATOLOGY

Last updated on 2020-29-05 at 01:08