THE DETECTION OF THE C-MYC AND RAS ONCOGENES IN NASOPHARYNGEAL CARCINOMA BY IMMUNOHISTOCHEMISTRY
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AbstractForty-one paraffin embedded specimens of primary nasopharyngeal carcinoma (NPC) were examined to investigate the expression of c-myc and ras oncogenes. Sections were stained with the monoclonal antibodies myc 1-9E10 or ras Y13-259 and binding was detected using the ABC method. The intensity of staining for each tumour was assessed as nil, moderate or intense. The results indicated that 9 (22%) had intense staining for the c-myc oncogene, 28 (68%) had moderate staining and only 4 (10%) showed no staining. For the ras oncogene, 8 (19%) had intense staining, 22 (54%) moderate staining and 11 (27%) showed no staining. The patient's clinical data indicated no correlation between the expression of either c-myc or ras p21 and age, sex, smoking, tumour stage, antibody titre to EBV, or family history. No correlation was found between ras p21 expression and survival; however, overexpression of the c-myc oncogene correlated with a poor prognosis (p < 0.05). This study is consistent with investigations demonstrating that c-myc expression correlates with poor survival in head and neck tumours.
All Author(s) ListPORTER MJ, FIELD JK, LEUNG SF, LO D, LEE JCK, SPANDIDOS DA, VANHASSELT CA
Journal nameActa Oto-laryngologica
Year1994
Month1
Day1
Volume Number114
Issue Number1
PublisherSCANDINAVIAN UNIVERSITY PRESS
Pages105 - 109
ISSN0001-6489
LanguagesEnglish-United Kingdom
KeywordsHEAD AND NECK CARCINOMA; SURVIVAL
Web of Science Subject CategoriesOtorhinolaryngology; OTORHINOLARYNGOLOGY

Last updated on 2021-19-04 at 00:27