QUANTITATIVE STUDY OF THE INTERPHASIC NUCLEOLAR ORGANIZER REGIONS IN 2 HUMAN CERVICAL-CARCINOMA CELL-LINES
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AbstractWe have studied the relationship between interphase nucleolar organizer regions (NORs) distribution and nucleolar size in cancer cells under prolonged culture. Sh morphometric parameters (NUCLEAR SIZE, NOR NUMB, AREA SUM, MEAN AREA, SIZE RATIO and SIZE RATIO MEAN) of AgNORs in cancer cells were analyzed by an image analyzing system. The results show that the parameters NORN NUMB, AREA SUM and NUCLEAR SIZE demonstrate the most consistent changes in the two cervical carcinoma cell lines studied. These three parameters of AgNORs appear to be correlated with the degree of ''dedifferentiation'' that occurred in tumor cells under prolonged culture.
All Author(s) ListCHEW EC, LIU TL, CHAM WK, CHIU SW, LEE JCK
Journal nameAnticancer Research
Year1993
Month11
Day1
Volume Number13
Issue Number6A
PublisherINT INST ANTICANCER RESEARCH
Pages2089 - 2094
ISSN0250-7005
eISSN1791-7530
LanguagesEnglish-United Kingdom
KeywordsAGNORS; CANCER CELL LINES; CC2; CC3; CERVICAL CARCINOMA
Web of Science Subject CategoriesOncology; ONCOLOGY

Last updated on 2020-29-05 at 01:03