BIOTRANSFORMATION OF PETHIDINE - A COMPARATIVE-STUDY OF 24 H URINE IN 3 ETHNIC-GROUPS
Publication in refereed journal

香港中文大學研究人員

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摘要219 surgical patients of either Caucasian, Chinese or Nepalese origin were given pethidine 1 mg/kg by intramuscular injection as pre-operative medication. Urine was collected for 24 h and analysed for pethidine, pethidinic acid, pethidinic acid conjugates, norpethidine, norpethidinic acid, and norpethidinic acid conjugates. The mean proportion of the percentage of metabolites attributable to oxidative demethylation, hydrolysis and conjugation was almost identical in each ethnic group (P > 0.2). It was concluded that there were no differences in the metabolic variability of the biotransformation of pethidine in Asians and Caucasians in whom the urine pH had not been acidified.
著者HOUGHTON IT, CHAN K, WONG YC, LEUNG DHY, AUN CST
期刊名稱European Journal of Drug Metabolism and Pharmacokinetics
出版年份1993
月份7
日期1
卷號18
期次3
出版社MEDECINE ET HYGIENE
頁次285 - 288
國際標準期刊號0378-7966
語言英式英語
關鍵詞CAUCASIANS; CHINESE; ETHNIC GROUPS; METABOLISM; NEPALESE; PETHIDINE; POLYMORPHISM
Web of Science 學科類別Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

上次更新時間 2020-21-11 於 23:55