A DOUBLE-BLIND RANDOMIZED COMPARISON OF PERINDOPRIL AND KETANSERIN IN THE TREATMENT OF HYPERTENSION IN ELDERLY DIABETIC-PATIENTS
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AbstractA double-blind, randomised study of the antihypertensive efficacy of perindopril and ketanserin in 44 elderly noninsulin-dependent diabetic patients aged greater-than-or-equal-to 60 years was conducted. Blood pressure, blood biochemical and haematological parameters, plasma vasoactive hormones, urinary volume, electrolytes and microalbumin were measured at baseline, after a 4-week placebo period, and at intervals during 8 weeks of treatment with active drug. Electrocardiogram and echocardiogram data were also obtained. Dosages of perindopril used were 2mg once daily for 4 weeks doubling to 4mg once daily if a target blood pressure of less-than-or-equal-to 160/90mm Hg was not reached. Dosages of ketanserin were 40mg twice daily increasing to 80mg twice daily.
All Author(s) ListWOO J, WOO KS, OR KH, COCKRAM CS, NICHOLLS MG
Journal nameDrugs and Aging
Year1993
Month11
Day1
Volume Number3
Issue Number6
PublisherADIS INTERNATIONAL LTD
Pages525 - 531
ISSN1170-229X
eISSN1179-1969
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesGeriatrics & Gerontology; GERIATRICS & GERONTOLOGY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2021-02-03 at 01:47