EFFECTS OF HYPERTHERMIA ON THE NUCLEOLAR PROTEINS IN TUMOR-CELLS
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摘要The effects of hyperthermia at 41-degrees-C and 43-degrees-C on the nucleolar protein B23 in Ehrlich ascites tumour (EAT), human glioblastoma U-87 MG and U-373 MG cell lines were studied. Cellular localization of protein B23 was detected by an immunofluorescence technique using monoclonal antibody against protein B23. Diminution of fluorescence in the nucleoli occurred when the cells were treated at high temperature. The decrease in fluorescence level depends on the treatment temperature and duration. Among the three cell lines studied, the U-373 MG glioblastoma was the least responsive to hyperthermia followed by the U-87 MG glioblastoma. The decrease in nucleolar fluorescence of the EAT cells treated at 41-degrees-C and 43-degrees-C correlated with their subsequent cell survival. Dispersion of the nucleolar argyrophilic granules occurred in EAT cells after heating at 43-degrees-C for 1 h. The possible implication of such effect is discussed in relation to the heat-sensitive elements in the nucleolus.
著者LUI CP, CHAN PK, FUNG KP, CHOY YM, LEE CY
期刊名稱Cancer Letters
出版年份1993
月份6
日期15
卷號70
期次1-2
出版社ELSEVIER SCI IRELAND LTD
頁次129 - 139
國際標準期刊號0304-3835
電子國際標準期刊號1872-7980
語言英式英語
關鍵詞HYPERTHERMIA; NUCLEOLAR PROTEINS; PROTEIN-B23; SILVER STAINING
Web of Science 學科類別Oncology; ONCOLOGY

上次更新時間 2020-09-08 於 02:43